High density marker panels, SNPs prioritizing and accuracy of genomic selection
نویسندگان
چکیده
منابع مشابه
High density marker panels, SNPs prioritizing and accuracy of genomic selection
Background: The availability of high-density (HD) marker panels, genome wide variants and sequence data creates an unprecedented opportunity to dissect the genetic basis of complex traits, enhance genomic selection (GS) and identify causal variants of disease. The disproportional increase in the number of parameters in the genetic association model compared to the number of phenotypes has led t...
متن کاملGenomic selection using low-density marker panels.
Genomic selection (GS) using high-density single-nucleotide polymorphisms (SNPs) is promising to improve response to selection in populations that are under artificial selection. High-density SNP genotyping of all selection candidates each generation, however, may not be cost effective. Smaller panels with SNPs that show strong associations with phenotype can be used, but this may require separ...
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Genomic selection has been widely implemented in national and international genetic evaluation in the dairy cattle industry, because of its potential advantages over traditional selection methods and the availability of commercial high-density (HD) single nucleotide polymorphism (SNP) panels. However, this method may not be cost-effective for cow selection and for other livestock species, becau...
متن کاملEffects of Marker Density, Number of Quantitative Trait Loci and Heritability of Trait on Genomic Selection Accuracy
The success of genomic selection mainly depends on the extent of linkage disequilibrium (LD) between markers and quantitative trait loci (QTL), number of QTL and heritability (h2) of the traits. The extent of LD depends on the genetic structure of the population and marker density. This study was conducted to determine the effects of marker density, level of heritability, number of QTL, and to ...
متن کاملEffect of marker density and trait heritability on the accuracy of genomic prediction over three generations
The aim of this study was to determine the effect of marker density, level of heritability, number of QTLs, and size of training set on the genomic accuracy over three generations. Thereby, a trait was simulated with heritability of 0.10, 0.25 or 0.40. For each animal, a genome with 20 chromosomes, 1 Morgan each, was simulated. Different marker densities (2000, 4000 and 6000 markers) and 400 an...
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ژورنال
عنوان ژورنال: BMC Genetics
سال: 2018
ISSN: 1471-2156
DOI: 10.1186/s12863-017-0595-2